And 8 am says Dr. Prednisone is not to be taken randomly during the day. How Long Does It Take Prednisone To Work Dr Megan It is best to take prednisone in the morning with breakfast. . This can lead to withdrawal symptoms. Taking prednisone too late in the evening can cause sleeplessness and insomnia too. This is why they suggest taking it all in the morning. Taking your dose of prednisone too late in the evening may cause difficulty sleeping. If you are on daily prednisone experts recommend taking the dose in the morning to reduce this risk. Time Day Best Take Prednisone - Cheapest Prices. Make sure you also take your dose of prednisone with food and just FYI grapefruit juice has no effect on prednisone. If you are taking Prednisone just once a day take it in the morning with breakfast. Your healthcare provider may. I dont take any food with it just a full glass of water to make sure the...